Cardiovasculaire
Nonmajor orthopedic surgery of the lower limbs that results in transient reduced mobility places patients at risk for venous thromboembolism. Rivaroxaban may be noninferior to enoxaparin with regard to the prevention of major venous thromboembolism in these patients.
Rivaroxaban was more effective than enoxaparin in the prevention of venous thromboembolic events during a period of immobilization after nonmajor orthopedic surgery of the lower limbs. (Funded by Centre Hospitalier Universitaire de Saint-Etienne and Bayer; PRONOMOS ClinicalTrials.gov number, NCT02401594. opens in new tab.)
We thank Alain Baleydier, Annaëlle David, and Julie Bisiaux (of PSNResearch) for contributions to the trial and Sophie Rushton-Smith (of MedLink Healthcare Communications) for medical writing assistance with an earlier version of the manuscript under the direction of the authors.